Autophagy dictates sensitivity to PRMT5 inhibitor in breast cancer
Abstract Protein arginine methyltransferase 5 (PRMT5) catalyzes mono-methylation and symmetric di-methylation on arginine residues and has emerged as a potential antitumor target bracket front roller with inhibitors being tested in clinical trials.However, it remains unknown how the efficacy of PRMT5 inhibitors is regulated.Here we report that auto